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Colloquium Seminar Series: Jumin Lee, Nemes Fellow, Lehigh University | Biological Sciences

Oct 19, 2017
4:10 PM - 5:00 PM

Iacocca Hall - B-023
111 Research Drive
Bethlehem PA 18015

Delia Chatlani

The ganglioside-mimicry lipopolysaccharides of Campylobacter jejuni (C. jejuni) are the major cause of Guillain-Barré syndrome (GBS) and Miller-Fisher syndrome (MFS). However, the molecular-level understanding on how C. jejuni elicits GBS and MFS is elusive. This research aimed to develop tools to build glycolipid- and/or LPS-containing membrane systems, and characterize structural and dynamic properties of gangliosides in axolemma as well as ganglioside-mimicry LPS in C. jejuni outer membranes (OMs) using molecular dynamics (MD) simulation technique.

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