Colloquium Seminar Series: Sara Lynn Farwell, Lehigh | Biological Sciences
Mar 23, 2017
4:10 PM - 5:00 PM
Iacocca Hall - B-023
111 Research Drive
Bethlehem PA 18015
Speaker Sara Lynn Farwell, Nemes Fellow, Department of Biological Sciences, Lehigh University.
Novel Heparin Receptor TMEM184A Regulates Blood Vessel Regeneration in the Zebrafish
Angiogenesis is the formation of new vasculature from existing vasculature. It is a tightly controlled process and occurs normally during development and wound healing. Dysregulated angiogenesis is implicated in several diseases, including cardiovascular disease, stroke, cancer, wet macular degeneration, and others. There are several protein players involved in regulating the balance between pro- and anti-angiogenic factors. Heparin/heparan sulfate proteoglycans on the surface of blood vessels are one of these important players that interact simultaneously with growth factors and their receptors during angiogenesis. Recently, our lab has published the in vitro identification and function of a novel heparin receptor in vascular cells, transmembrane protein 184A (TMEM184A). TMEM184A is a highly conserved protein but its function in vivo remains uncharacterized. We are examining the in vivo function(s) of TMEM184A using the adult zebrafish regenerating caudal fin as a model for angiogenesis. TMEM184A is specifically expressed in the blood vessels of both mature and regenerating fin. Transient knock down of TMEM184A using morpholinos results in aberrant vasculature characterized by a reduction in total and vascular regeneration, an increase in endothelial cell proliferation, and regions of tangled blood vessels. This data suggests that TMEM184A may be playing a major regulatory role during angiogenesis. These are important first steps towards understanding the function(s) of TMEM184A during angiogenesis and evaluating its therapeutic potential.
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